Journal
CURRENT CARDIOLOGY REVIEWS
Volume 7, Issue 4, Pages 214-220Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340311799960645
Keywords
Left ventricular dysfunction; doxorubicin; oxidant stress
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Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.
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