Journal
BONE
Volume 46, Issue 1, Pages 91-100Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2009.09.008
Keywords
Maxillary Sinus Augmentation; Tissue-engineered Bone; Confocal Laser Scanning Microscope (CLSM); Canine
Categories
Funding
- National Natural Science Foundation of China [30400502, 30772431, 30973342]
- Program for New Century Excellent Talents in University [NCET-08-0353]
- Science and Technology Commission of Shanghai Municipality [07DZ22007, 08410706400, 08JC1414400, 08DZ2271100, 0952 nm04000]
- Shanghai Rising-star Program [05QMX1426, 08QH14017]
- Shanghai Education Committee [Y0203, T0202, 07SG19]
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The objective of this study is to systematically evaluate the effects of a tissue-engineered bone complex for maxillary sinus augmentation in a canine model. Twelve sinus floor augmentation surgeries in 6 animals were performed bilaterally and randomly repaired with the following 3 groups of grafts: group A consisted of tissue-engineered osteoblasts/beta-TCP complex (n = 4); group B consisted of beta-TCP alone (n = 4); group C consisted of autogenous bone obtained from iliac crest as a positive control (n = 4). All dogs had uneventful healings following the surgery. Sequential polychrome fluorescent labeling, maxillofacial CT, microhardness tests, as well as histological and histomorphometric analyses indicated that the tissue-engineered osteoblasts/beta-TCP complex dramatically promoted bone formation and mineralization and maximally maintained the height and volume of elevated maxillary sinus. By comparison, both control groups of beta-TCP or autologous iliac bone showed considerable resorption and replacement by fibrous or fatty tissue. We thus conclude that beta-TCP alone could barely maintain the height and volume of the elevated sinus floor, and that the transplantation of autogenous osteoblasts on beta-TCP could promote earlier bone formation and mineralization, maximally maintain height, Volume and increase the compressive strength of augmented maxillary sinus. This tissue engineered bone complex might be a better alternative to autologous bone for the clinical edentulous maxillary sinus augmentation. (C) 2009 Elsevier Inc. All rights reserved.
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