Journal
NEUROLOGY RESEARCH INTERNATIONAL
Volume 2011, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2011/124256
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Funding
- Bayerische Forschungsstiftung, Munich, Germany
- Bavarian State Ministry of Sciences, Research and the Arts (ForNeuroCell grant)
- Regenion GmbH
- German Federal Ministry of Education and Research (BMBF) [0312134, 01GG0706, 01GA0505, 01GN0978]
- state of Salzburg
- EU-FP6-project DiMI [LSHB-CT2005-512146]
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The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.
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