Journal
JOURNAL OF CLINICAL PATHOLOGY
Volume 68, Issue 4, Pages 309-313Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jclinpath-2014-202521
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Funding
- Addenbrooke's Charitable Trust
- Human Research Tissue Bank - NIHR Cambridge Biomedical Research Centre
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Background Endothelin-1 (ET-1) acting through endothelin A and B receptors (ETAR and ETBR) has been implicated in the development of cancer. The endothelin axis has not previously been characterised in human pancreatic adenocarcinoma (PAC). Methods Expression of ET-1, ETAR, ETBR, vascular endothelial growth factor and microvessel density (MVD) was determined by immunohistochemistry in 45 surgically resected human PACs and 15 non-cancer human pancreas samples. Results PAC had the highest staining intensity for ET-1 and ETBR: 38% PAC samples scored 2+ or more compared with 7% non-cancer sample in ET-1; 58% PAC samples scored 2+ compared with 0% non-cancer samples in ETBR. MVD was significantly lower in PAC compared with non-cancer tissue (p<0.0001). Conclusions PAC was characterised by greater expression of ET-1 and ETBR compared with normal pancreas.
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