Journal
BONE
Volume 42, Issue 5, Pages 832-836Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2008.01.021
Keywords
osteoporosis; monitoring; treatment; bone density; markers of bone turnover
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Most of the currently available anti-osteoporosis medications promptly and significantly influence the rate of bone turnover. Biochemical markers of bone turnover now provide a high sensitivity to change, allowing the detection of these bone turnover changes within a couple of weeks. Since the anti-fracture efficacy of inhibitors of bone resorption or stimulators of bone formation appears to be largely independent of baseline bone turnover, biochemical markers do not appear to play a significant role in the selection of one particular drug, for an individual patient. However, there are consistent data showing that short-term changes in biochemical markers of bone turnover may be significant predictors of future changes in bone mineral density or fracture reduction, hence suggesting that bone turnover markers play a significant role in the monitoring of anti-osteoporosis therapy. (c) 2008 Elsevier Inc. All rights reserved.
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