Journal
ASIAN JOURNAL OF CHEMISTRY
Volume 23, Issue 1, Pages 166-168Publisher
ASIAN JOURNAL OF CHEMISTRY
Keywords
Chloroform; Catalase; Glutathione; Malondialdehyde; Erythrocytes
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Funding
- Cukurova University [FBE.2000.13, FEF2002BAP4]
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The objectives of this study is to assess the effects of the chloroform on erythrocytes by measuring the Na+-K(+)ATPase (EC.3.6.1.39) and catalase (EC 1.11.1.6) activities and also the amount of reduced glutathione and malondialdehyde. In vitro exposure of intact human erythrocytes or freshly prepared erythrocyte membranes to chloroform for different contact times (0, 6, 12, 24, 48 h) resulted in the inhibition of erythrocyte membrane Na+-K(+)ATPase activity in a time dependent manner. The results also indicated that catalase activity, glutathione and malondialdehyde levels were sensitive parameters for chloroform.
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