Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 10, Issue 9, Pages 1185-1194Publisher
TAYLOR & FRANCIS INC
DOI: 10.1586/ERC.12.102
Keywords
allogeneic; autologous; cardiac tissue derived; cardiosphere-derived cells; cardiospheres; cellular therapy; heart disease; intracoronary; infusion; intramuscular injection
Categories
Funding
- ALLSTAR Phase 2
- NIH
- California Institute for Regenerative Medicine
- Cedars-Sinai Board of Governors Heart Stem Cell Center
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Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.
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