Journal
MEDCHEMCOMM
Volume 3, Issue 1, Pages 61-64Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00203a
Keywords
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Funding
- Greenwich University (GRE)
- CRUK
- Malaysian Government
- Biochemical and Biophysical Sciences Research Council
- University of Southampton
- Watercress Alliance
- Multiple Myeloma Research Foundation
- National Institutes of Health
- EPSRC
- Canadian Institutes for Health Research
- Canadian Foundation for Innovation
- Genome Canada through the Ontario Genomics Institute
- GlaxoSmithKline
- Karolinska Institutet
- Knut and Alice Wallenberg Foundation
- Ontario Innovation Trust
- Ontario Ministry for Research and Innovation
- Merck Co Inc.
- Novartis Research Foundation
- Swedish Agency for Innovation Systems
- Swedish Foundation for Strategic Research
- Wellcome Trust
- EPSRC [EP/I037229/1] Funding Source: UKRI
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A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.
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