Journal
BIOCHEMISTRY RESEARCH INTERNATIONAL
Volume 2012, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/248135
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Funding
- Wellcome Trust project [086658, 093228, 094759]
- Biotechnology and Biological Sciences Research Council
- SUSLA
- Open Lab Foundation
- Engineering and Physical Sciences and Medical Research Councils
- Wolfson Research Institute
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Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline themajor pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.
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