Journal
TRANSCRIPTION-AUSTIN
Volume 3, Issue 3, Pages 106-109Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.19816
Keywords
alternative pre-mRNA splicing; DNA methylation; RNA polymerase II
Categories
Funding
- Intramural Research Program of the NIH
- National Cancer Institute
- Center for Cancer Research
- NATIONAL CANCER INSTITUTE [ZIABC011293] Funding Source: NIH RePORTER
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DNA methylome analysis in a variety of species has revealed elevated 5-methyl-cytosine at exons relative to introns. These associations raised the possibility that intragenic DNA methylation aids the spliceosome in the process of exon definition. Here, I highlight recent genome-wide associations and direct evidence linking DNA methylation to pre-mRNA splicing.
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