Journal
CURRENT RADIOPHARMACEUTICALS
Volume 5, Issue 3, Pages 187-201Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1874471011205030187
Keywords
Titanium-44; Scandium-44; Radionuclide generator; Post-processing; DOTA; Octreotide; Positron emission; PET
Funding
- COST [D38, BM0607]
- DFG [DFG RO 985 / 18]
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Ti-44/(44) Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of Sc-44 and its high positron branching of 94.27% may stimulate the application of Sc-44-labeled PET radiopharmaceuticals. This review describes the current status of Ti-44 production, Ti-44/(44) Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc-III co-ordination chemistry, proof-of-principle labeling of Sc-44-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.
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