Journal
TRANSCRIPTION-AUSTIN
Volume 3, Issue 4, Pages 181-186Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.20720
Keywords
enhancer; long-range interactions; chromosome conformation capture; chromatin looping; transcription elongation; Myb; transcription regulatory networks
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Funding
- Netherlands Genomics Initiative
- Dutch Cancer Genomics Center
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Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the non-coding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.
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