Journal
POLISH JOURNAL OF MICROBIOLOGY
Volume 61, Issue 2, Pages 95-104Publisher
POLSKIE TOWARZYSTWO MIKROBIOLOGOW-POLISH SOCIETY OF MICROBIOLOGISTS
DOI: 10.33073/pjm-2012-012
Keywords
antibiotics; bacteriophages; nanoparticles; plant compounds; synergy
Categories
Funding
- Polish Ministry of Science and Higher Education [NN 302 027937]
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Due to the alarming spread of resistance to classic antimicrobial agents, innovative therapeutic methods to combat antibiotic-resistant bacterial pathogens are urgently required. This minireview examines the enhancement of antibiotic efficacy by their combination with new antimicrobials, such as plant-derived compounds, metal ions and nanoparticles and bacteriophage lytic enzymes. The mechanisms of the observed synergy are also described. The promising results of basic research indicate that in future, combined therapy may be applied in human and veterinary medicine, agriculture and the food industry to combat bacterial pathogens.
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