Journal
INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY
Volume -, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1687-9856-2012-14
Keywords
PCOS; Insulin resistance; Insulin sensitivity; Anovulation; Hyperandrogenemia; Premature pubarche; Diabetes mellitus; Beta cell function
Categories
Funding
- AMDeC (Academy for Medical Development and Collaboration)
- NIH [1 UL1 RR024156-01]
- Insulin Resistance in Adolescents at High Risk for Polycystic Ovary Syndrome [K23 HD40325]
- Cedars-Sinai General Clinical Research Center Grant from the NCRR [M01-RR000425]
Ask authors/readers for more resources
Background: First-degree relatives (FDRs) of women with PCOS are at increased risk for impaired insulin sensitivity and diabetes mellitus. Glucose tolerant FDR have evidence of insulin resistance and hyperinsulinemia prior to emergence of frank PCOS. Aim: To study insulin dynamics parameters in the early adolescent FDR of women with PCOS. Methods: This is a cross-sectional study involving 18 adolescents whose mothers or sisters had been diagnosed with PCOS and 21 healthy, age-matched control adolescents without FDR. Subjects underwent anthropometric measurements, steroid profiling and frequently sampled Intravenous Glucose Tolerance Test (IVGTT), Homeostasis Model Assessment (HOMA) index, Glucose Disposal Index (GDI), Acute Insulin Response (AIR) and Quantitative insulin sensitivity check index (QUICKI) were derived from IVGTT results. Results: FDRs showed significantly higher mean HOMA and lower GDI. There were no differences in mean age or BMI Z-score between the cohorts. No differences in sex steroids or AIR were identified between groups. Conclusion: Female adolescent FDR of women with PCOS have higher HOMA index and lower QUICKI, reflecting altered insulin sensitivity and lower GDI reflecting poorer beta-cell function. The presence of multiple risk factors for type 2 diabetes suggests that aggressive screening of the early adolescent FDR of women with PCOS is indicated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available