Journal
MEDICAL MYCOLOGY CASE REPORTS
Volume 1, Issue 1, Pages 20-23Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mmcr.2012.02.001
Keywords
Aspergillosis; Itraconazole; Mycosis; IgE; Skin test; Alternaria
Categories
Funding
- Fungal Research Trust
- The Medical Research Council
- The Chronic Granulomatous Disease Research Trust
- National Institute of Allergy
- Infectious Diseases, National Institute of Health Research
- European Union
- AstraZeneca
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While allergic bronchopulmonary aspergillosis and mycosis are well recognised, no cases have been described related to Alternaria spp. Alternaria is a common sensitising fungus in asthmatics and related to thunderstorm asthma. We report a case of an asthmatic who presented with worsening asthma control, mild eosinophilia on high dose inhaled corticosteroids (800 mu g/day), a total IgE of 3800 KIU/L, an Alternaria-specific IgE of 21.3 KUa/L and positive skin prick test, negative specific IgE and skin prick test to Aspergillus fumigatus, Penicillium spp., Cladosporium spp., Trichophyton spp. and a normal CT scan of the thorax. He responded well to a short course of oral prednisolone and then oral itraconazole, given over 17 months but relapsed 1 month after stopping it. (C) 2012 International Society for Human and Animal Mycology. Published by Elsevier B.V.
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