Journal
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
Volume 5, Issue -, Pages 213-220Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CCID.S29664
Keywords
antiaging agent; scar correction; stretch marks; signaling molecules; photoaging; biostimulation
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Background: The reduction of mortality worldwide has led older individuals to seek - intervention modalities to improve their appearance and reverse signs of aging. Objective: We formulated a medical device as innovative block-polymer nanoparticles based on phosphatidylcholine, hyaluronan, and chitin nanofibrils entrapping amino acids, vitamins, and melatonin. Methods: Viability and collagen synthesis were controlled on fibroblasts ex vivo culture while adenosine triphosphate production was evaluated on keratinocytes culture. Subjective and objective evaluations were performed in vivo on selected volunteer patients. Results: In accordance with our previous studies, both the in vitro and in vivo obtained resultsdemonstrate the efficacy of the injected block-polymer nanoparticles in reducing skin wrinkling and - ameliorating the signs of aging.
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