Journal
BREAST CANCER-BASIC AND CLINICAL RESEARCH
Volume 6, Issue -, Pages 9-19Publisher
SAGE PUBLICATIONS LTD
DOI: 10.4137/BCBCR.S8513
Keywords
microRNA-10b; breast cancer metastasis; nanoparticles
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Funding
- US Department of Defense Breast Cancer Postdoctoral Fellowship [W81XWH-10-1-0031]
- NIH National Institute of General Medical Sciences [R01GM080987]
- DOE
- Battelle for DOE [DE-AC05-76RL01830]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM080987] Funding Source: NIH RePORTER
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Recent studies revealed that micro RNA-10b (mir-10b) is highly expressed in metastatic breast cancer cells and positively regulates breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis. In this study we designed anti-mir-10b molecules and combined them with poly L-lysine (PLL) to test the delivery effectiveness. An RNA molecule sequence exactly matching the mature mir-10b minor antisense showed strong inhibition when mixed with PLL in a wound-healing assay with human breast cell line MDA-MB-231. The resulting PLL-RNA nanoparticles delivered the anti-microRNA molecules into cytoplasm of breast cancer cells in a concentration-dependent manner that displayed sustainable effectiveness.
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