Journal
BMC NEUROLOGY
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2377-12-103
Keywords
Multiple sclerosis; T-cell proliferation; Vitamin D
Categories
Funding
- Fundacio La Marato de TV3 [07/2410]
- Spanish Ministry of Science and Innovation
- Blood and Tissue Bank [PTQ-09-02-017050]
- stabilization program of Biomedical researches of the ISCIII [CES07/015]
- Direccio d'Estrategia I Coordinacio, Health Department of Catalonia
Ask authors/readers for more resources
Background: Low levels of plasma 25-hydroxyvitaminD (25(OH) D) are associated with a higher incidence of multiple sclerosis (MS) due to the immune suppressive properties of vitamin D. The aim of this study was to determine the correlation between plasma 25(OH) D concentrations and clinical and immunological variables in a cohort of multiple sclerosis patients. Methods: Plasma 25(OH) D concentrations were evaluated in summer and winter in 15 primary progressive MS (PPMS) patients, 40 relapsing- remitting MS (RRMS) patients and 40 controls (HC). Protocol variables included demographic and clinical data, radiological findings and immunological variables (oligoclonal bands, HLADR15 and T-lymphocyte proliferation to a definite mix of 7 myelin peptides). Results: During the winter, plasma concentrations were significantly lower in RRMS patients compared to HC, whereas no differences were found in summer. No relationships were found between plasma 25(OH) D concentrations and clinical or radiological variables. RRMS patients with a positive T-cell proliferation to a mix of myelin peptides (n = 31) had lower 25(OH) D concentrations. Conclusions: 25(OH) D is an immunomodulatory molecule that might have a regulatory role in T-cell proliferation to myelin peptides in RRMS patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available