Journal
BMC NEUROLOGY
Volume 11, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1471-2377-11-75
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Funding
- Romanian Government [POSDRU/89/1.5/S/64109]
- Executive Unit for Financing Higher Education, Research, Development and Innovation - Romania (UEFISCDI) [41-013/2007]
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Background: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach. Discussion: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a neuroregenerative reserve, that could be exploited by growth factors or stem cells-neurorestoration therapies. Summary: In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.
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