Journal
BMC MUSCULOSKELETAL DISORDERS
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2474-14-90
Keywords
Animal model; Tendinitis; Tendinopathy; Tendinosis; Overuse
Categories
Funding
- CIHR [126604-1] Funding Source: Medline
Ask authors/readers for more resources
Background: The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Methods: Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15 degrees incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis. Results: There were no significant group differences within each of the individual histopathological categories assessed (all p >= 0.16) or for total histopathological score (p = 0.14). Conclusions: Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available