4.7 Article

Molecular Evolution of Respiratory Syncytial Virus Fusion Gene, Canada, 2006-2010

Journal

EMERGING INFECTIOUS DISEASES
Volume 18, Issue 1, Pages 120-124

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1801.110515

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Funding

  1. Canadian Institutes of Health Research
  2. Abbott Laboratories Ltd.

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To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006-2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.

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