Journal
BMC MUSCULOSKELETAL DISORDERS
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2474-10-20
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Funding
- Korea Health Industry Development Institute
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Background: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts. Methods: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable. Results: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment. Conclusion: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.
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