Journal
PLANT SIGNALING & BEHAVIOR
Volume 8, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/psb.22865
Keywords
virus infection; replication complex; protein inclusion; aggresome Tobacco mosaic virus; microtubules; endoplasmic reticulum; ER-assisted protein degradation
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Funding
- Swiss National Science Foundation
- Zurich-Basel Plant Science CenterSyngenta fellowship
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Cell-division-cycle protein 48 (CDC48) is an essential, conserved ATP-driven chaperone in eukaryotic cells that functions in diverse cellular processes, including the targeting of misfolded and aggregated proteins for degradation via proteasomal and aggresomal-autophagic pathways. We recently demonstrated that plant CDC48 localizes to and interacts with Tobacco mosaic virus (TMV) movement protein (MP) in ER-associated viral protein inclusions. Our data suggest that CDC48 participates in the clearance of these viral protein inclusions in an ER-assisted protein degradation (ERAD)-like mechanism. As TMV MP-inclusions formed at late infection stages resemble aggresomes, we here propose that TMV MP enters both ERADlike and aggresomal pathways in its host cells and that CDC48 coordinates these processes. Moreover, as viruses often exploit host pathways for replication and spread, we propose a model in which CDC48 functions in the degradation pathway of overaccumulating viral protein and also actively participates in the regulation of TMV replication and cell-to-cell movement.
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