Journal
BMC MICROBIOLOGY
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2180-14-148
Keywords
Carbapenemases; E. coli; ST405; Class 1 integron
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Background: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla(NDM-4) gene were investigated. Results: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and beta-lactams. The strains produced the NDM-4 carbapenemase and the bla(NDM-4) gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). Conclusions: This is the first report on the emergence of an MDR strain of E. coli producing the NDM-4 MBL in Italy.
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