Journal
BMC MICROBIOLOGY
Volume 10, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1471-2180-10-126
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Funding
- Kempestiftelserna
- Lions Cancer Research Foundation and Cancerforskningsfonden Norrland
- Percy Falks stiftelse for forskning betraffande prostatacancer och brostcancer
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Background: The immune stimulating bacterium Propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. To understand the pathogenesis of the earliest phase of this infection, we examined the P. acnes triggered immune response in cultivated prostate epithelial cells. Results: Prostate epithelial cells are triggered to secrete IL-6, IL-8 and GM-CSF when infected with P. acnes. The secretion of cytokines is accompanied by NF kappa B related upregulation of the secreted cytokines as well as several components of the TLR2-NF kappa B signaling pathway. Conclusions: P. acnes has potential to trigger a strong immune reaction in the prostate glandular epithelium. Upon infection of prostate via the retrograde urethral route, the induced inflammatory reaction might facilitate bacterial colonization deeper in the prostate tissue where persistent inflammation may impact the development of prostate diseases as hyperplasia and/or malignancy.
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