Journal
CHILD DEVELOPMENT
Volume 84, Issue 1, Pages 49-57Publisher
WILEY
DOI: 10.1111/j.1467-8624.2012.01793.x
Keywords
-
Categories
Funding
- CIHR Funding Source: Medline
- NIMH NIH HHS [T32 MH018268] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH018268] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Although epidemiological data provide evidence that early life experience plays a critical role in human development, the mechanism of how this works remains in question. Recent data from human and animal literature suggest that epigenetic changes, such as DNA methylation, are involved not only in cellular differentiation but also in the modulation of genome function in response to early life experience affecting gene function and the phenotype. Such modulations may serve as a mechanism for life-long genome adaptation. These changes seem to be widely distributed across the genome and to involve central and peripheral systems. Examining the environmental circumstances associated with the onset and reversal of DNA methylation will be critical for understanding risk and resiliency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available