Journal
STATA JOURNAL
Volume 13, Issue 1, Pages 77-91Publisher
STATA PRESS
DOI: 10.1177/1536867X1301300106
Keywords
st0284; metacumbounds; trial sequential analysis; cumulative meta-analysis; information size; Lan-DeMets bounds; monitoring boundary; cumulative z score; heterogeneity
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We present a new command, met acumbounds, for the estimation of trial sequential monitoring boundaries in cumulative meta-analyses. The approach is based on the Lan-DeMets method for estimating group sequential boundaries in individual randomized controlled trials by using the package ldbounds in R statistical software. Through Stata's metan command, metacumbounds plots the Lan-DeMets bounds, z-values, and p-values obtained from both fixed and random-effects cumulative meta-analyses. The analysis can be performed with count data or on the hazard scale for time-to-event data.
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