Journal
TRANSCRIPTION-AUSTIN
Volume 4, Issue 4, Pages 158-161Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.25395
Keywords
retinoic acid; epigenetic; embryonic stem cell; OCT4; CRABPI; ERK; TR2
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Funding
- Distinguished McKnight University Professorship
- [DK60521]
- [DK54733]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK054733, R01DK060521] Funding Source: NIH RePORTER
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Non-canonical cytoplasmic activities and signal transduction of retinoic acid (RA) expand RA's pleiotropic effects in coordinating the epigenome in embryonic stem cell (ESC). Examples include RA-bound cellular retinoic acid binding protein I, which activates ERK2. By engaging both cytosolic and nuclear mediators, RA can efficiently augment ESC's epigenome.
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