Journal
CASE REPORTS IN NEUROLOGY
Volume 5, Issue 3, Pages 149-154Publisher
KARGER
DOI: 10.1159/000354828
Keywords
Hypogammaglobulinemia; Idiopathic CD4+ T-lymphocytopenia; JC virus; Progressive multifocal leukoencephalopathy
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Background: Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease or immunosuppression-associated condition. Case Report: We present a 72-year-old previously healthy woman who developed a progressive neurological condition affecting the entire nervous system which led to her death within 5 months. PML was diagnosed at autopsy. Conclusion: PML should be considered in patients with progressive neurological disorders involving the white matter, even in the absence of previous immunomodulatory treatment or immunosuppression. (C) 2013 S. Karger AG, Basel
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