Journal
INTERNATIONAL JOURNAL OF INFLAMMATION
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/348092
Keywords
-
Categories
Funding
- NIH [R01 AI041592-15, R01 GM99111-18, P30 AR48335-12, U54 HL112303-01, R01 EY018636, R01 EY019037]
- Edward N. and Della L. Thome Memorial Foundation
- Alexion Pharmaceuticals
- Sybil B. Harrington Special Scholar award for Macular Degeneration from Research to Prevent Blindness
- National Institutes of Health [R01EY019320]
- Department of Veterans Affairs [I01 RX000444]
- Foundation Fighting Blindness
- Beckman Initiative for Macular Research
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
- NATIONAL EYE INSTITUTE [K08EY021189, R01EY019037, R01EY018636, R01EY019320] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U54HL112303] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041592] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P30AR048335] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM099111] Funding Source: NIH RePORTER
- Veterans Affairs [I01RX000444] Funding Source: NIH RePORTER
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Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries; with the aging population, the negative health impacts and costs of the disease will increase dramatically over the next decade. Although the exact cause of AMD is unknown, genetic studies have implicated the complement system as well as other immune responses in disease pathogenesis and severity. Furthermore, histologic studies have shown the presence of macrophages, lymphocytes, and mast cells, as well as fibroblasts, in both atrophic lesions and with retinal neovascularization. This review summarizes discussions from the fifth annual conference of the Arnold and Mabel Beckman Initiative for Macular Research by the Inflammation and Immune Response Task Force. These deliberations focused on the role of inflammatory immune responses, including complement, inflammasomes, adaptive immune responses, and para-inflammation, unanswered questions and studies to address these questions, and potential immune-related therapeutic targets for AMD.
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