Journal
JOURNAL OF CLINICAL NEUROLOGY
Volume 11, Issue 4, Pages 297-304Publisher
KOREAN NEUROLOGICAL ASSOC
DOI: 10.3988/jcn.2015.11.4.297
Keywords
neural stem cells; stroke; phosphatidylinositol-3-kinases; regeneration
Categories
Funding
- Korea Research Foundation [2012R1A1B3000473]
- NanoBio R&D Program of the Korea Science and Engineering Foundation - Ministry of Education, Science and Technology [2007-04717]
- National Research Foundation of Korea [2012R1A1B3000473] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Neurologic deficits resulting from stroke remain largely intractable, which has prompted thousands of studies aimed at developing methods for treating these neurologic sequelae. Endogenous neurogenesis is also known to occur after brain damage, including that due to cerebral infarction. Focusing on this process may provide a solution for treating neurologic deficits caused by cerebral infarction. The phosphatidylinositol-3-kinase (PI3K) pathway is known to play important roles in cell survival, and many studies have focused on use of the PI3K pathway to treat brain injury after stroke. Furthermore, since the PI3K pathway may also play key roles in the physiology of neural stem cells (NSCs), eliciting the appropriate activation of the PI3K pathway in NSCs may help to improve the sequelae of cerebral infarction. This review describes the PI3K pathway, its roles in the brain and NSCs after cerebral infarction, and the therapeutic possibility of activating the pathway to improve neurologic deficits after cerebral infarction.
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