Journal
BMC GENOMICS
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2164-15-S12-S11
Keywords
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Funding
- Fundamental Research Funds for the Central Universities [2662014PY001]
- RSF [14-24-00123]
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Background: Long-range chromatin interactions play an important role in transcription regulation. Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET) is an emerging technology that has unique advantages in chromatin interaction analysis, and thus provides insight into the study of transcription regulation. Results: This article introduces the experimental protocol and data analysis process of ChIA-PET, as well as discusses some applications using this technology. It also unveils the direction of future studies based on this technology. Conclusions: Overall we show that ChIA-PET is the cornerstone to explore the three-dimensional (3D) chromatin structure, and certainly will lead the forthcoming wave of 3D genomics studies.
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