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Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

Journal

GENOME BIOLOGY
Volume 15, Issue 8, Pages -

Publisher

BMC
DOI: 10.1186/s13059-014-0449-4

Keywords

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Funding

  1. European Community [259015 COLTHERES]
  2. AIRC [9970]
  3. AIRC IG [12812]
  4. Fondazione Piemontese per la Ricerca sul Cancro-ONLUS 5 per mille Ministero della Salute
  5. Ministero dell'Istruzione, dell'Universita e della Ricerca (progetto PRIN)

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DNA fragments released from cancer cells into the blood can be used to generate molecular profiles of tumors. Non-invasive 'liquid biopsies' can be used to monitor minimal residual disease and detect the emergence of drug resistance.

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