Journal
BIOMEDICAL REPORTS
Volume 2, Issue 1, Pages 7-11Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2013.199
Keywords
miRNA; miR-181b; oncogene; tumor suppressor gene; regulator
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Funding
- National Natural Science Foundation of China [81171653, 30972703]
- Natural Science Foundation of Jiangsu province [BK2011246, BK2011247]
- Project of Six Batch of Major Talent Summit [BRA2010037]
- Society Development Plans, Department of Science and Technology, Changzhou [CJ20112020, CZ20110024, CS20102020]
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MicroRNAs (miRNAs or miRs) are small, non-coding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level to repress protein expression of target genes. Among these, miR-181b has been found to be a critical regulatory miRNA linking inflammation and cancer. The functional significance of miR-181b in various tumors and translational research suggests that it exhibits great potential as a predictive and prognostic biomarker. Extensive efforts are underway to identify mRNA targets and the affected regulatory networks, which may be the key to providing a better understanding of miR-181b-mediated signaling pathways.
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