Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 54, Issue 2, Pages 259-264Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02419-15
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Funding
- NIAID NIH HHS [R21 AI103612] Funding Source: Medline
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Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile toxins provide new tools for diagnosis and, potentially, for management of C. difficile infection (CDI). Compared to methods that detect toxigenic organism, ultrasensitive toxin detection may allow diagnosis of CDI with increased clinical specificity, without sacrificing clinical sensitivity; measurement of toxin levels may also provide information relevant to disease prognosis. This minireview provides an overview of these new toxin detection technologies and considers what these new tools might add to the field.
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