Journal
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnint.2014.00035
Keywords
anterior cingulate cortex; pain; pain affect; place escape; place avoidance
Categories
Funding
- National Institute of Drug Abuse
- Advance Research Project program of the State of Texas
- American Psychological Association
- University of Texas at Arlington
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The neural network that contributes to the suffering which accompanies persistent pain states involves a number of brain regions. Of primary interest is the contribution of the cingulate cortex in processing the affective component of pain. The purpose of this review is to summarize recent data obtained using novel behavioral paradigms in animals based on measuring escape and/or avoidance of a noxious stimulus. These paradigms have successfully been used to study the nature of the neuroanatomical and neurochemical contributions of the anterior cingulate cortex (ACC) to higher order pain processing in rodents.
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