Journal
GUT MICROBES
Volume 5, Issue 2, Pages 220-224Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.27290
Keywords
Crohn disease; ulcerative colitis; macrophage; heme oxygenase; carbon monoxide
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Funding
- National Institutes of Health [R01 DK54452, T32 DK007737, F32 DK083186]
- Crohn's and Colitis Foundation of America Research Fellowship Award
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK054452, F32DK083186, T32DK007737] Funding Source: NIH RePORTER
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Heme oxygenase-1 (HO-1) and its enzymatic by-product carbon monoxide (CO) have emerged as important regulators of acute and chronic inflammation. Mechanisms underlying their anti-inflammatory effects are only partially understood. In this addendum, we summarize current understanding of the role of the HO-1/CO pathway in regulation of intestinal inflammation with a focus on innate immune function. In particular, we highlight our recent findings that HO-1 and CO ameliorate intestinal inflammation through promotion of bacterial clearance. Our work and that of many others support further investigation of this global homeostatic pathway in the human inflammatory bowel diseases (IBDs).
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