Journal
GUT MICROBES
Volume 5, Issue 5, Pages 663-668Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/19490976.2014.969984
Keywords
breastfeeding; gut microbiota; gene expression; intestinal epithelial cells; inflammatory bowel disease; polymeric immunoglobulin receptor; secretory IgA
Categories
Funding
- NIH [AI069027, NCATS UL1TR000117, NCRR 5P20RR016481-12, NIGMS 8 P20 GM103436-12]
- Crohn's and Colitis Foundation of America (CCFA)
- Kentucky Bioinformatics Research Infrastructure Network
- CCFA
- NATIONAL CANCER INSTITUTE [P30CA177558] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000117] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016481] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI069027] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103436] Funding Source: NIH RePORTER
Ask authors/readers for more resources
From birth to adulthood, the gut microbiota matures from a simple community dominated by a few major bacterial groups into a highly diverse ecosystem that provides both benefits and challenges to the host. Currently there is great interest in identifying environmental and host factors that shape the development of our gut microbiota. Breast milk is a rich source of maternal antibodies, which provide the first source of adaptive immunity in the newborn's intestinal tract. In this addendum, we summarize our recent data demonstrating that maternal antibodies in breast milk promote long-term intestinal homeostasis in suckling mice by regulating the gut microbiota and host gene expression. We also discuss important unanswered questions, future directions for research in this field, and implications for human health and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available