Journal
GUT MICROBES
Volume 5, Issue 3, Pages 369-380Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.28681
Keywords
microbiota-gut-brain axis; neurodevelopment; metabolism; hypothalamic-pituitary-adrenal axis; gut microbiota; short chain fatty acids; beta-hydroxybutyrate; glucose
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Funding
- Swedish Medical Research Council (VR)
- Hjarnfonden
- Lee Kong Chain School of Medicine Nanyang Technological University funds
- Singapore National Medical Research Council Translational and Clinical Research Program [NMRC/TCR/003-GMS/2008]
- Duke-NUS Block Funding
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Brain development is an energy demanding process that relies heavily upon diet derived nutrients. Gut microbiota enhance the host's ability to extract otherwise inaccessible energy from the diet via fermentation of complex oligosaccharides in the colon. This nutrient yield is estimated to contribute up to 10% of the host's daily caloric requirement in humans and fluctuates in response to environmental variations. Research over the past decade has demonstrated a surprising role for the gut microbiome in normal brain development and function. In this review we postulate that perturbations in the gut microbial-derived nutrient supply, driven by environmental variation, profoundly impacts upon normal brain development and function.
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