Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 1, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/23723548.2014.963438
Keywords
dicentric; KU; Lig4; Mre11; NHEJ; Rap1; telomere; TRF2
Categories
Funding
- ARC
- ANR (Blanc-SVSE-8-2011-TELODICENs)
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The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable dicentric chromosome, NHEJ must be prevented from acting on telomeres. Multiple mechanisms mediated by telomere factors act in synergy to achieve this inhibition.
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