Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 125, Issue 1, Pages 85-93Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI73946
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Funding
- Bio-TechMed-Graz
- NAWI Graz
- Austrian Science Fund FWF [I1000, P23490-B12, P24381-B20]
- Ligue Contre le Cancer (Equipe Labelisee)
- Agence National de la Recherche (ANR)
- Association Pour la Recherche sur le Cancer (ARC) of the Canceropole Ile-de-France
- AXA Chair for Longevity Research of the Institut National du Cancer (INCa)
- Fondation Bettencourt-Schueller
- Fondation de France
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- LabEx Immuno-Oncology
- SIRIC Stratified Oncology Cell DNA Repair
- Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- Austrian Science Fund (FWF) [P 23490, P 24381] Funding Source: researchfish
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Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.
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