Journal
BMC DEVELOPMENTAL BIOLOGY
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-213X-14-2
Keywords
Notch; Skeletal muscle; Quiescence; Regeneration
Categories
Funding
- Institut Pasteur
- Association Francaise contre le Myopathies
- Agence Nationale de la Recherche Laboratoire d'Excellence Revive, Investissement d'Avenir [ANR-10-LABX-73]
- EU
- Association pour la Recherche sur le Cancer
- Fondation pour la Recherche Medicale
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Notch signalling acts in virtually every tissue during the lifetime of metazoans. Recent studies have pointed to multiple roles for Notch in stem cells during quiescence, proliferation, temporal specification, and maintenance of the niche architecture. Skeletal muscle has served as an excellent paradigm to examine these diverse roles as embryonic, foetal, and adult skeletal muscle stem cells have different molecular signatures and functional properties, reflecting their developmental specification during ontology. Notably, Notch signalling has emerged as a major regulator of all muscle stem cells. This review will provide an overview of Notch signalling during myogenic development and postnatally, and underscore the seemingly opposing contextual activities of Notch that have lead to a reassessment of its role in myogenesis.
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