Journal
CURRENT NUTRITION & FOOD SCIENCE
Volume 10, Issue 3, Pages 181-186Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573401310666140529205646
Keywords
alpha-amylase; alpha-glucosidase; beta-glucuronidase; black tea; flavonoids; gallic acid; lipase
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Funding
- UGC
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The objective of the present study was to determine the inhibitory properties of the infusions and decoctions of four samples of Indian black tea ( BT) and some of the tea flavonoids, gallic acid and caffeine, in vitro, against beta-glucuronidase, lipase, alpha-amylase and alpha-glucosidase. These enzymes are related to liver disorders, obesity and diabetes. The phenolic constituents and caffeine content in the BT extracts were measured quantitatively by HPLC. It was noted that both infusion and decoction of BT had beta-glucuronidase inhibitory property close to that of silymarin. Epigallocatechin gallate, epicatechin, and gallocatechin showed higher beta-glucuronidase inhibitory activity than that of BT extracts and silymarin. BT extracts also inhibited the enzyme lipase. Thearubigin, theaflavin, epigallocatechin gallate, epicatechin and gallocatechin showed significant lipase inhibitory properties that were superior to the drug orlistat. The tea extracts, flavonoids and gallic acid inhibited the activity of alpha-amylase and alpha-glucosidase. Theaflavin and catechin had alpha-amylase inhibitory activity better than that of acarbose. This in vitro study reveals that BT extract and the phenolic components may have potential benefit for controlling liver disorders, obesity and diabetes.
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