Journal
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1472-6882-14-183
Keywords
Myocardial ischemia; Tumor; Angiogenesis; PNS; Bidirectional regulation; miR-18a
Categories
Funding
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Program for Pu Jiang Scholar at Science and Technology Commission of Shanghai Municipality [11PJ1409000, 13PJ1407800]
- Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [13SG42]
- National Natural Science Foundation of China [81273960]
- Funding for Outstanding Junior Faculties at Shanghai Institutions of Higher Learning [ZZszy12048]
- Three-year Projects to Promote Traditional Chinese Medicine, Shanghai [ZYSNXD-CC-ZDYJ050]
- Key Disciplines of Clinical Integrative Medicine at the State Administration of Traditional Chinese Medicine of China
Ask authors/readers for more resources
Background: Panax Notoginseng Saponins (PNS) is the major class of active constituents of notoginseng, a natural product extensively used as a therapeutic agent in China. Tumor when accompanied by cardiovascular disorders poses a greater challenge for clinical management given the paradoxical involvement of angiogenesis, therefore gaining increased research attention. This study aim to investigate effects of PNS and its activity components in the mouse model of tumor complicated with myocardial ischemia. Methods: Tumor complexed with myocardial ischemia mouse model was first established, which was followed by histological and immunohistochemistry examination to assess the effect of indicated treatments on tumor, myocardial ischemia and tissue specific angiogenesis. MicroRNA (miRNA) profiling was further carried out to identify potential miRNA regulators that might mechanistically underline the therapeutic effects of PNS in this complex model. Results: PNS and its major activity components Rg1, Rb1 and R1 suppressed tumor growth and simultaneously attenuated myocardial ischemia. PNS treatment led to decreased expression of CD34 and vWF in tumor and increased expression of these vascular markers in heart. PNS treatment resulted in reduced expression of miR-18a in tumor and upregulated expression of miR-18a in heart. Conclusions: Our data demonstrated for the first time that PNS exerts tissue specific regulatory effects on angiogenesis in part through modulating the expression of miR-18a, which could be responsible for its bidirectional effect on complex disease conditions where paradoxical angiogenesis is implicated. Therefore, our study provides experimental evidence warranting evaluation of PNS and related bioactive component as a rational therapy for complex disease conditions including co-manifestation of cancer and ischemic cardiovascular disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available