Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 125, Issue 3, Pages 939-948Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI76305
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Funding
- Rosetrees Trust
- National Institute of Health Research University College London Hospitals Biomedical Research Centre
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Bariatric surgery is the most effective treatment for severe obesity, producing marked sustained weight loss with associated reduced morbidity and mortality. Roux-en-Y gastric bypass surgery (RYGBP), the most commonly performed procedure, was initially viewed as a hybrid restrictive-malabsorptive procedure. However, over the last decade, it has become apparent that alternative physiologic mechanisms underlie its beneficial effects. RYGBP-induced altered feeding behavior, including reduced appetite and changes in taste/food preferences, is now recognized as a key driver of the sustained postoperative weight loss. The brain ultimately determines feeding behavior, and here we review the mechanisms by which RYGBP may affect central appetite-regulating pathways.
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