Journal
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1472-6882-12-137
Keywords
Chinese herbs; Gan-Lu-Yin; Migration; Restenosis; Vascular smooth muscle cell
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Funding
- National Science Council [NSC 100-2320B-039-014-]
- China Medical University [CMU99-TC-29]
- Department of Health Clinical Trial and Research Center of Excellence [DOH101-TD-B-111004, DOH101-TD-B-111-005]
- National Science Council
- Ministry of Education, Taiwan, Republic of China, under the ATU plan [NSC 101-2311-B-005-006-MY3]
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Background: This study was to explore the effects of Gan-Lu-Yin (GLY) on the migration of vascular smooth muscle cells (VSMCs) induced by fetal bovine serum and on neointima formation in a rat model of carotid artery balloon injury. Methods: VSMCs were treated with different concentrations of GLY, and then analyzed with Flow cytometric analysis, zymography, transwell, and western blotting. SD rats received balloon-injury were analyzed with H&E staining. Results: Our results showed that GLY significantly decreased the thickness of neointima. The inhibition by non-cytoxic doses of GLY of VSMCs migration was through its negative regulatory effects on phosphorylated ERK1/2, PI3K/AKT, and FAK. The data showed that GLY can inhibit the migration of VSMCs cells, and might block injury-induced neointima hyperplasia via the inhibition of VSMCs migration, without inducing apoptosis. Conclusions: These observations provide a mechanism of GLY in attenuating cell migration, thus as a potential intervention for restenosis.
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