Journal
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1472-6882-12-172
Keywords
Qol; EORTC QLQ-C30; QLQ-STO22; 5-FU; Viscum album
Categories
Funding
- Abnoba GmbH
- Abnoba Korea co. Ltd.
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Background: Mistletoe (Viscum album L.) extracts are widely used in complementary cancer therapy. Aim of this study was to evaluate safety and efficacy of a standardized mistletoe extract (abnobaVISCUM (R) Quercus, aVQ) in patients with gastric cancer. Patients and Methods: 32 operated gastric cancer patients (stage Ib or II) who were waiting for oral chemotherapy with the 5-FU prodrug doxifluridine were randomized 1: 1 to receive additional therapy with aVQ or no additional therapy. aVQ was injected subcutaneously three times per week from postoperative day 7 to week 24 in increasing doses. EORTC QLQ-C30 and -STO22 Quality of Life questionnaire, differential blood count, liver function tests, various cytokine levels (tumor necrosis factor (TNF)-alpha, interleukin (IL)-2), CD 16(+)/CD56(+) and CD 19(+) lymphocytes were analyzed at baseline and 8, 16 and 24 weeks later. Results: Global health status (p < 0.01), leukocyte-and eosinophil counts (p <= 0.01) increased significantly in the treatment group compared to the control group. Diarrhea was less frequently reported (7% vs. 50%, p=0.014) in the intervention group. There was no significant treatment effect on levels of TNF-alpha, IL-2, CD16(+)/CD56(+) and CD 19(+) lymphocytes and liver function tests measured by ANOVA. Conclusion: Additional treatment with aVQ is safe and was associated with improved QoL of gastric cancer patients.
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