Journal
TRANSCRIPTION-AUSTIN
Volume 5, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.28726
Keywords
alternative splicing; coupling between transcription and splicing; chromatin; long-range chromatin interactions
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Funding
- Agencia Nacional de Promocion de Ciencia y Tecnologia of Argentina (ANPCYT)
- University of Buenos Aires
- Department of Environmental Sciences, Faculty of Meteorology, Environment and Arid Land Agriculture, King Abdulaziz University, Saudi Arabia
- Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)
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Splicing is a predominantly co-transcriptional process that has been shown to be tightly coupled to transcription. Chromatin structure is a key factor that mediates this functional coupling. In light of recent evidence that shows the importance of higher order chromatin organization in the coordination and regulation of gene expression, we discuss here the possible roles of long-range chromatin organization in splicing and alternative splicing regulation.
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