Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 125, Issue 5, Pages 1790-1792Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI81507
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Funding
- Swedish Research Council
- Swedish Diabetes Association
- Novo Nordisk Foundation
- Torsten Soderberg Foundation
- West Sweden ALF program
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the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded that an abdominal distribution of fat for a given BMI is associated with increased insulin resistance and risk of developing type 2 diabetes and cardiovascular disease. The correlation between abdominal fat and metabolic dysfunction has since been validated in many studies, and waist circumference is now a criterion for the diagnosis of metabolic syndrome. Several mechanisms for this relationship have been postulated; however, we now know that visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue cannot accommodate excess fat because of its limited expandability.
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