Journal
TRANSCRIPTION-AUSTIN
Volume 5, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/21541272.2014.944039
Keywords
antisense transcription; asRNA; double-stranded RNA; Hfq; pervasive transcription; promoter; RNA; RNase III; spurious transcription; sigma factor; transcriptome
Categories
Funding
- Austrian Science Fund [FWF I538-B12, F4301]
- University of Vienna
- Portland State University
- Collins Medical Trust
- American Heart Association
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Pervasive, or genome-wide, transcription has been reported in all domains of life. In bacteria, most pervasive transcription occurs antisense to protein-coding transcripts, although recently a new class of pervasive RNAs was identified that originates from within annotated genes. Initially considered to be non-functional transcriptional noise, pervasive transcription is increasingly being recognized as important in regulating gene expression. The function of pervasive transcription is an extensively debated question in the field of transcriptomics and regulatory RNA biology. Here, we highlight the most recent contributions addressing the purpose of pervasive transcription in bacteria and discuss their implications.
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